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Discovering microbes  by high-throughtput single-cell genomics

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Microbial Single-Cell Genomics is a research group at the Institute for Integrative Systems Biology (I2SysBio), a research center of the University of Valencia and the Spanish National Research Council (CSIC), located in Paterna, Valencia, Spain. 

We explore the microbial dark matter by the cutting edge techniques in metagenomics and single-cell genomics.

We are dedicated to the discovery of new bacteria and viruses through high-throughput single-cell DNA sequencing. We focus on elucidating interesting functions of microbes without the need to culture them, since most of the environmental microbes are not easily culturable in the lab. We have three main research lines: connecting bacteria with viruses and other mobile genetic elements, symbiosis of bacteria and nudibranchs and microbes in extreme industrial environments.

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Our research mentioned in news

UNIVERSITY OF VALENCIA • JULY 2026

Museomics revealing new symbionts of nudibranchs:
Ca. Felimaribacter and Ca. Polyceribacter

UNIVERSITY OF VALENCIA • NOVEMBER 2025

CleanBar: new bioinformatic tool for demultiplexing of split-and-pool barcoding in single-cell genomics

UNIVERSITY OF VALENCIA • MAY 2025

DNA extraction methods for long read sequencing of nudibranch genomes

UNIVERSITY OF VALENCIA • JULY 2023

Ca. Doriopsillibacter, new symbiont of a nudibranch Doriopsilla, discovered by function-based single-cell genomics

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